Acute kidney injury (AKI) is defined as an abrupt (within hours) reduction in kidney function, which encompasses both injury (structural damage) and impairment (loss of function). Many patients with AKI have a mixed etiology where sepsis, ischemic, and nephrotoxicity often co-exist and complicate recognition and treatment.^[1] Common signs and symptoms of AKI include decreased urine output, edema, dyspnea, fatigue, and loss of appetite. Hyperkalemia, hyponatremia, and intravascular overload are common complications of AKI. Management is based on treating the underlying cause of AKI, but supportive care—via fluid management, vasopressor therapy, kidney replacement therapy (KRT), and more—is also crucial.^[2]