Detection and evaluation of chronic kidney disease (CKD) primarily involves assessing glomerular filtration rate (GFR), which is now widely estimated based on serum creatinine levels.1 Estimated GFR helps assess renal function, severity of disease, appropriate drug dosing, and renal involvement in systemic diseases. Renal function tests, including serum creatinine, plasma urea, urine volume, and minerals in urine, monitor renal damage and help determine the underlying etiology. The ideal GFR marker, such as inulin, is metabolically inert and cleared only by the kidneys.2 Other markers like creatinine and urea are also used, though each has limitations. While creatinine clearance is useful, it can be inaccurate at low GFR and affected by drugs. Advanced methods, including radiolabeled compounds, can further assess kidney function.