Hypertension in CKD
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Dr. Ametashver Singh
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Chronic kidney disease (CKD) and hypertension (HTN) share a complex, bidirectional relationship—declining kidney function raises blood pressure, while sustained hypertension accelerates CKD progression. This harmful feedback loop is well-documented in both animal models and clinical studies. In the Chronic Renal Insufficiency Cohort (CRIC) study of 3612 adults with CKD, 86% reported hypertension compared to 29% in the general population. Hypertension becomes increasingly prevalent and harder to control as CKD advances.1 Intensive blood pressure lowering has been shown to reduce the risk of kidney failure events by 17% and end-stage kidney disease by 18%, especially in patients with proteinuria.2 Effective management of hypertension in CKD includes identifying the underlying renal pathology, setting appropriate BP goals, and implementing both non-pharmacological and pharmacological interventions.