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Challenges and Best Practices for Managing Anemia in Non-Dialysis Chronic kidney Disease

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Chronic kidney disease (CKD) is extremely common and has emerged as one of the leading non-communicable causes of death worldwide. It has been substantiated that approximately 1 in 10 individuals are affected by CKD. Anemia is a common complication in CKD, and is associated with a reduced quality of life, and an increased morbidity and mortality.1 In CKD, anemia develops when the glomerular filtration rate (GFR) decreases to < 60 mL/min/1.73 m2. With CKD disease progression, the prevalence of anemia increases. Common symptoms of anemia in CKD include dyspnea, fatigue, generalized weakness, headache, decreased concentration, dizziness, and reduced exercise tolerance. Moreover, up to 60% of patients with non-dialysis dependent CKD develop anemia and around 50% of patients with non-dialysis dependent CKD have iron deficiency.